Videos tagged with “fundamentals”

Now that we have our Gen Chem fundamentals down, we journey into the land of Alkanes, our first true taste of Organic Chemistry. This series, albeit not what I consider to be the most fun part of OChem, is where we learn to name molecules (with common names and IUPAC nomenclature), how molecules orient themselves in space and how that affects their internal energy, and our very first reaction & mechanism: free radical halogenation. So buckle up--the organic party is truly about to get started.

With our first reaction and mechanism in the books, we now usher in a topic of Organic Chemistry called Stereochemistry. This series kicks off with a brief overview of isomerism (structural, geometric, and most importantly stereo) and then shifts completely to stereochemistry. We'll discuss, what stereochemistry is, how to identify a stereocenter, how to assign R or S configuration to a stereocenter, how to determine relationships between molecules based on their stereochemistry, and more. Stereochemistry is one of those things that will ALWAYS come back in both semesters of Organic Chemistry, so make sure to be comfortable with the concepts before charging onward.

Alright, jOeCHEMists. Our Gen Chem foundations are strong. We handled Alkanes with ease. We've taken our Stereochemistry vitamins. Now begins what I consider the fun part of Organic Chemistry. In this series, we'll tackle Sn2, E2, Sn1, and E1, and we'll do so by taking each reaction pathway one at a time and exploring it in depth. Once we fully understand a pathway, we'll solidify our knowledge through LOTS of examples for that specific pathway. Then, once we have a good handle on all four, we'll put ourselves to the ultimate test and solve problems without knowing what kind of reaction they are. Our knowledge of Sn2, E2, Sn1, and E1 will allow us to decipher how a reaction will proceed based on the conditions present, and believe it or not, we'll have to lean on everything we've learned prior as well.

jOeCHEMists, I know I said it before, but NOW the real fun begins. Up until this point we've been filling our organic toolbox full of skills, and it's time we put our foot on the gas. It's time to learn reactions. It's time to learn mechanisms. It's time to learn how to design organic syntheses and solve synthesis problems. And we start this new chapter of our journey with alcohols. In this series, we're going to learn how to oxidize & reduce alcohols as well as how to perform Sn2 on them (even though alcohols aren't great leaving groups). But, most importantly, we'll learn the Grignard Reaction--marking a huge moment in our organic careers. The Grignard Reaction allows us to make carbon-carbon connections, and that will lead us straight into tackling our first synthesis problem. There's a lot of fun to be had in this section, gang. Let's get it.

Fresh off of our conquest of alcohols, we move straight into some relatives of the alcohol functional group: ethers and epoxides. We'll start things off with a recap and discussion regarding carbocation stability and shifts. Then, we'll move on to talk about reactions of ethers and how to use them as protecting groups. Finally, we'll round out the series by looking at attacking epoxides and how the regiochemistry of attacks changes based on acidic vs basic conditions.

Okay, jOeCHEMists. That little NMR honeymoon nicely recharged our batteries, but we have some unfinished business in our OChem I journey. Our next stop is Alkenes, and I won't lie to you, gang: there is a lot of information in this series. If you find yourself a bit overwhelmed, that's okay. When I was learning this stuff for the first time, I certainly did. But once you see the information a few times, you organize the reactions + mechanisms (which I've already done for you and linked to all the videos :D), you'll see that everything we've learned up until now applies and will propel you to master these new concepts. And, this might be a stretch, but I think you'll find this chemistry fun and cool. So let's show Alkenes who's boss.

Gang. jOeCHEMists. We've made it to the end of Organic Chemistry I. But don't take your foot off the gas--we need to give Alkynes the respect it deserves and finish strong the semester strong. Luckily, much of the chemistry we'll talk about is an extension of the concepts we learned in the Alkenes series: we just have an extra bond! But, we'll certainly learn new chemistry, such as hydrogenating triple bonds, how to make terminal alkynes good nulceophiles, and keto-enol tautomerism. Let's finish OChem I with a bang, gang.

jOeCHEMists, welcome to Organic Chemistry II. If you're here, that means you've taken on OChem I and came out the other side a stronger warrior than when you entered. Now, with one semester of chemistry in the books, we look forward to the second half of our carbon conquest, and we begin with Conjugation. In this series, we'll explore the stabilizing effect of lining up many carbons in a row that have p orbitals parallel to each other. After we understand conjugation, we'll see how that affects reaction we've done in the past, and then we'll round out the series with a brand new reaction--the Diels Alder reaction. So, gang: OChem II. Let's get after it.

Fresh off of our introduction to conjugation, we now understand the powerful stabilizing effect of having a network of consecutive atoms with unhybridized p orbitals parallel to one another. Well, in this series, we take it to the next level with the concept of aromaticity. Benzene is going to become our best friend in this series, and we'll see how, even though it is rock solid stable due to its aromaticity, to do chemical transformations with benzene and benzene derivatives. We'll learn a basic set of reactions, extra helper reactions, and we'll discuss how to control regiochemistry with various directing groups.

Gang. jOeCHEMists. Now that we've made good friends with conjugation, aromaticity, and benzene, we're going to shift our focus elsewhere to some old, familiar friends: carbonyls (specifically ketones and aldehydes). We're going to learn a lot of reactions in this series. We're going to learn a lot of mechanisms in this series. There is a lot of information. In. This. Series. My biggest piece of advice is to practice the mechanisms (forward and reverse direction) and truly understand the concepts going on. Taking a memorization approach will have you lost in a sea of acetals, imines, enamines, etc. But don't worry: This is manageable, and the chemistry is wicked cool.

jOeCHEMists, now that we've explored more of the awesome chemistry we can do at the carbonyl position, we have to look no further than the next door neighbor for our next challenge: the alpha carbon. We'll start things off by exploring alpha deprotonation, why it works and how it enables us to generate a new class of nucleophiles that we were initially exposed to with keto-enol tautomerism at the end of OChem I. After learning how to make enolates and enols, we're going to tackle a group of reactions that allow us to make carbon-carbon bonds. There's so much cool chemistry in this series, and it's where I personally discovered that I wanted OChem in my future/life. I hope you feel the same. Leddoit.

Alright, gang. We've revisited aldehydes and ketones, functional groups we met in OChem I, and learned a lot more about them in OChem II. It's time to give carboxylic acids that same treatment. In this series, we're going to learn how to do much more chemistry with carboxylic acids than just acid-base reactions. And, what's nice, is that everything we're going to cover here is going to be helpful when we tackle derivatives of carboxylic acids, so you're unknowingly doing future you a favor.

Up until this point, nitrogen was always that atom whose formal charge was a bit annoying to calculate. Yeah, we've seen nitrogen in a lot of acid-base reactions, and sure, nitrogen came back into the spotlight when we learned about amides. But now, nitrogen gets its five seconds of fame. In this series, gang, we do a deep dive on amines. We'll discuss their physical properties as well as how to produce them (in ways you already knew but also with new pathways). So buckle up: It's nitrogen time.

jOeCHEMists, let me hit you with a blast from the past: remember Fischer Projections? Well if you did or didn't, they're about to re-enter your world. In this series, we're going to cover carbohydrates. This is certainly an interesting section of Organic Chemistry, because while we will learn some new reactions & mechanisms, we won't spend the majority of our time doign that like we would in a typical section. We'll learn a lot of nomenclature, conventions, methods to draw/represent carbohydates, and a few reactions along the way. It'll be sweet, trust me (heh, get it? Yeah, I'm sure you did. Look, I had to do it, sorry.).

Gang, we've been hitting reactions and mechanisms REALLY hard. So we're going to take a little detour and tackle a topic in Organic Chemistry that is truly different than any other we've conquered thus far. In real life, after you've performed a reaction and have a product mixture, you want to verify that your reaction worked and see how much product you made. Well HNMR is the gold standard for determining the structure(s) present in a solution/sample.

Practice exam and review materials for Organic Chemistry I Exam 1

Practice exam and review materials for Organic Chemistry I Exam 2

Practice exam and review materials for Organic Chemistry I Exam 3

If after the aromaticity + benzene series you found yourself craving more aromatic adventures, then I have some good news: you're in the right spot for round two. In this section, we massively deepen our knowledge regarding the chemistry we can do with benzene derivatives. We'll talk about ipso substitutions, EAS reactions with phenol, various rearrangements, and a whole lot more. We're even going to see a triple bond INSIDE of a benzene ring. It sounds whack. It sounds crazy. But, just like everything else we've learned together, we're going to master it.

Okay, gang, we've done A LOT of chemistry up to this point. We've seen many a reaction, countless mechanisms, and likely hundreds of cyclic structures. However, in all the rings we've seen, we haven't done a ton of chemistry with what are called heterocycles: rings with more than one type of atom in them. Well, that changes in this section. In this section, we'll be doing chemistry with cyclic structures that of course have carbon in them but also oxygen, nitrogen, and even sulfur. We'll even learn mechanistically how to make pyridine. The chemisty is cool and the rings are different--let's have ourselves a time.

Learn about biologically relevant organic molecules.

Comprehensive practice exam and review materials for Organic Chemistry II Final Exam