The Hydroxymethylation of Phenol
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https://joechem.io/videos/162 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link). https://joechem.io/videos/162 for video on jOeCHEM and attached worksheet + solution (below video on jOeCHEM aka the link). In this video, we'll take a look how we can use a phenoxide ion (phenol following deprotonation) to attack formaldehyde. This process is called hydroxymethylation, and in the case of phenol, it produces both ortho & para quinomethane. After we deep dive on the hydroxymethylation mechanism, we'll then see what other chemistry we can do with the quinomethanes produced.